Obese men are at increased risk for erectile dysfunction (ED), likely caused by atherosclerosis-related hypertension and cardiovascular disease, as well as hormonal changes associated with http://www.liebertpub.com/owm

As many as 30-40% of men over the age of 50 may experience ED, and both obesity and physical inactivity may increase their risk. The build-up of atherosclerotic plaque in the arteries of obese men can damage the arterial lining and contribute to elevated blood pressure. In addition to atherosclerosis, the hormonal changes that accompany obesity, including lower testosterone, increase the risk of ED. The modifiable risk factors for heart disease, such as excess weight, diabetes, and hypertension, are generally the same as those for ED. Studies have shown that weight loss and increased physical activity can improve ED.

Adam Gilden Tsai, MD, MSCE, from the University of Colorado Denver, and David Sarwer, PhD, from the University of Pennsylvania School of Medicine, describe a 48-year-old man with mild obesity (weight = 197 lbs, body mass index = 32.6 kg/m2 ) and hypertension who suffers from ED in the article “Obesity and Erectile Dysfunction.” Even with the use of ED medication (tadalafil, Cialis, Eli Lilly), he was not able to achieve an erection adequate for intercourse. After dietary counseling, a 4.6% weight reduction, and medication to lower his blood pressure to within the normal range (112/77 mm Hg), the patient has been able to achieve adequate erections with the use of ED medication as needed.

The authors emphasize that “the complicated interplay of weight and other health conditions relate to common medical symptoms, such as ED. We are reminded that atherosclerosis can cause not only macrovascular disease such as heart attack and stroke, but also microvascular disease, of which ED is one example.”

“If you are looking for another reason to lose weight, research now suggests that erectile dysfunction can improve with weight loss,” says James O. Hill, PhD, Editor-in-Chief of Obesity and Weight Management, Professor of Pediatrics and Medicine and Director of the Center for Human Nutrition and of the Colorado Clinical Nutrition Research Unit at the University of Colorado Denver.

Source:
Vicki Cohn

Mary Ann Liebert, Inc./Genetic Engineering News

View drug information on Cialis.

When most of us think of a yeast infection, we think of it in connection with women. However, the Candida albicans fungus (yeast) can cause infections in anyone of either gender, because it is present in all of our bodies. This will come as an unwelcome surprise to men, but hang on, because it gets worse. Guys, when you have sex with a woman who has yeast infection, she can easily pass it on to you.

Due to the specific hormones women have, they are more susceptible to yeast infections. Usually when a woman has an infection she will experience all of the uncomfortable symptoms that tell her what’s going on. She’ll know when it’s necessary to take more precautions in having sex. However, there are times when she may experience such mild symptoms that she’s unaware she even has a problem, so she can pass the infection on to a man without knowing it.

Most men don’t even think about being concerned over getting a yeast infection, but it can happen. In fact, yeast infections of the penis are very common and seldom cause any symptoms in otherwise healthy men. During an active yeast infection in either partner, it is safer to avoid sex altogether. This practice will not only ensure that the infection won’t be passed on, but it will also avoid more irritation which will make the condition last longer.

In order to know if you have a yeast infection, it will help if you know the symptoms. In women the most common symptoms are irritation, itching, redness, swelling, burning, and a whitish-grey discharge that has the consistency of cheese as well as a smell much like yeast or beer.

Men who are infected will show redness, irritation, and possibly white spots on the end of the penis. There may also be a white to yellow discharge present. It could be that after he has intercourse his penis will be sore. The better your overall health is, though, the milder the symptoms you’ll experience.

Both men and women should see a physician if they are concerned that they might have yeast infection. Your doctor will be able to confirm the diagnosis and make suggestions for effective treatments. There are numerous prescription, over-the-counter and natural remedies for treating yeast infection available.

If one partner in a sexual relationship has yeast infection, both partners should get diagnosed and treated. Otherwise, the person who was treated and is now symptom-free will run the risk of getting it back from their untreated partner every time they have sex.

Yeast infections can be a nuisance and wreak havoc with your sex life, but with proper treatment and precautions, soon you’ll both be healed up and back in action.

It is very important that you let your partner know of the risks involved. Sharing a tender moment is great, sharing an infection is not. Learn the facts and learn more about what options are available to you.

An innovative drug-delivery system nanoparticles encapsulating nitric oxide or prescription drugs shows promise for topical treatment of erectile dysfunction (ED), according to a new study by scientists at Albert Einstein College of Medicine of Yeshiva University.

The new system, tested successfully on a small number of animals, could potentially prevent side effects associated with oral ED medications, if study results can be replicated in humans. That could mean safer and more effective ED therapy for millions of men with heart disease and other health problems affecting erectile function. The study is published today in the online edition of the Journal of Sexual Medicine.

Tens of millions of men worldwide have benefited from oral ED medications such as sildenafil (stroke or have severe heart disease should use these drugs with caution or not at all. In addition, “an estimated 30 to 50 percent of men with ED do not respond to oral use of PDE5 inhibitors,” says senior author Kelvin P. Davies, Ph.D., associate professor of urology at Einstein.

The drug-delivery system, developed by Einstein scientists, consists of nanoparticles each smaller than a grain of pollen that can carry tiny payloads of various drugs or other medically useful substances and release them in a controlled and sustained manner.

The limited number of topical formulations of ED drugs has so far proven ineffective. This study was done to evaluate whether the Einstein nanoparticles, which have been shown to penetrate the skin, might allow the targeted delivery of compounds that treat ED and thereby avoid the drugs’ systemic effects.

An effective topical therapy could be especially significant for those ED patients particularly men with diabetes who have reduced levels of nitric oxide (NO), the signaling molecule that dilates blood vessels responsible for erectile activity. These men, who often aren’t helped by oral PDE5 inhibitor drugs, may benefit from direct application of NO or the PDE5 inhibitors.

The nanoparticles were tested on a total of 18 rats bred to have age-related ED. The rats were divided into three treatment groups. One group of seven rats received nanoparticles encapsulating NO. A second group of five rats received nanoparticles encapsulating NO plus an experimental ED drug called sialorphin (which has a mechanism of action different from PDE5 inhibitors). A third group of six received nanoparticles encapsulating NO plus tadalafil (Cialis).

Five of the seven rats treated with the NO-containing nanoparticles, and all 11 rats treated with nanoparticles encapsulating NO plus sialorphin or tadalafil showed significantly improved erectile function. None of the seven rats in a control group, which received empty nanoparticles, showed any improvement.

“Most of the animals, nearly 90 percent, showed a response to treatment with the nanoparticles,” says co-author Joel M. Friedman, M.D., Ph.D., professor of physiology & biophysics and of medicine. Dr. Friedman developed the nanoparticles with his son Adam Friedman, M.D., chief resident in the division of dermatology of the department of medicine at Montefiore Medical Center, The University Hospital and Academic Medical Center for Einstein.

“The response time to the nanoparticles was very short, just a few minutes, which is basically what people want in an ED medication,” adds Dr. Davies. “In both rats and humans, it can take 30 minutes to one hour for oral ED medications to take effect.”

Postmortem examination of the tissues at the site of administration showed no signs of local inflammation or toxicity. “In addition, when we applied the nanoparticles at therapeutic doses, we found no indication of systemic side effects,” says Dr. Friedman.

The Einstein research team will carry out safety and dosing studies in rats in the coming months. Clinical studies on humans could begin in a few years if animal studies continue to show that the nanoparticle delivery system is safe and effective. But the investigators caution that the time from a proof-of-concept trial in animals to approved use in humans may be a decade or more.

The paper, “Nanoparticles as a novel delivery vehicle for therapeutics targeting erectile dysfunction,” is published in the September 18, 2009 online edition of the Journal of Sexual Medicine. The lead authors are George Han, an M.D.-Ph.D. student at Einstein, and Moses Tar, M.D., assistant professor of urology at Einstein. Dwaraka Srinivasa Rao Kuppam, a technician in the Einstein urology department, Adam Friedman, M.D., of Montefiore Medical Center, and Arnold Melman, M.D., chairman of urology at Einstein, also contributed to the research.

About Albert Einstein College of Medicine of Yeshiva University

Albert Einstein College of Medicine of Yeshiva University is one of the nation’s premier centers for research, medical education and clinical investigation. It is home to 2,775 faculty members, 625 M.D. students, 225 Ph.D. students, 125 students in the combined M.D./Ph.D. program, and 380 postdoctoral research fellows. In 2008, Einstein received more than $130 million in support from the NIH. This includes the funding of major research centers at Einstein in diabetes, AIDS. Other areas where the College of Medicine is concentrating its efforts include developmental brain research, neuroscience, cardiac disease, and initiatives to reduce and eliminate ethnic and racial health disparities. Through its extensive affiliation network involving eight hospitals and medical centers in the Bronx, Manhattan and Long Island which includes Montefiore Medical Center, The University Hospital and Academic Medical Center for Einstein the College of Medicine runs one of the largest post-graduate medical training programs in the United States, offering approximately 150 residency programs to more than 2,500 physicians in training

Source: Albert Einstein College of Medicine

View drug information on Viagra.

Does the idea of publicly removing your shirt this fast approaching summer make you uncomfortable? Do you dream of removing your shirt like other people do while you are out anywhere at anytime. Would you love to take it off with complete confidence but you hesitate because you have man boobs? Regardless of the situation you can get the help you are looking for and eliminate man boobs if you have the right information about all the treatment that options available for you to choose.

Some people may choose to have an operation. As you might imagine, operations are expensive and involve a long period to recover from. The procedure requires taking time off from work and does not always yield the desired results.

Oral medicine is another choice. Although this is simple to take, it’s expensive and does not work for everyone.

Exercise should be another part of the answer you are looking for and could obviously tighten up your pecs . However this doesn’t actually treat the basic problem.

Herbal supplements are also helping some who realize the correct ones and quantities to use.

The better treatment option for this trouble is usually a combining of treatments. For example one that brings the best facets of multiple treatment plans and makes them into one holistic and simple to follow plan that offers good results.

If you can know which food consumption, including exercise, and the naturally occurring herbs to take, you can be on your way out of your man boobs in a very short period of time. It’d be great to be self-confident in public and live your dream life this summer, right?

Removing your shirt in public in the summer months should not torture you! Do you dream of removing your shirt like other people do while you are out and about anywhere at anytime. Can you remove it with confidence or will you hesitate because of your man boobs? Correct info about all the treatment choices available is the what you need for getting rid of those man boobs soon.

Operation is the choice that some people are deciding on. As you would think an operation can cost a lot of money and take a long time to recover from. It leads to many people missing work as well as disappointment that stems from poor results of this procedure after an investment of a large amount of time and money.

Oral medication is another option. Obviously this is an easy solution, but it is expensive and not always that effective.

Exercise is a different part than the answer you are looking for and usually helps to tighten up your pecs after that. However When it comes to the fundamental problem, this does not exactly treat it.

Herbal supplements are also helping some who realize the correct ones and quantities to use.

The better way to treat this trouble is a combination of treatments available today. We can now combine the most effective attributes of several methods of treatment to make one holistic easy to follow procedure that is producing great results.

The best way of getting rid of your man boobs is to learn what food to eat,what exercise to do and what natural herbs to take. Would you like to be able to go out with confidence this summer and to live the life you have always wanted?

Though a large number of men are not aware of this, nitric oxide plays a very important role in helping them get hard and firm erections.

When you get sexually excited, your brain signals your body to increase the blood flow to the penis. It is in the walls of the blood vessels that supply blood to the penis that this chemical is released. It helps penis muscles to relax so that blood vessels can dilate or open up. When the blood vessels dilate they allow more blood to flow into the penile chambers and make it swell. This blood is trapped in the erectile tissue and an erections is achieved.

The production of this highly crucial chemical declines with age and this decline not only affects male libido but also impairs your ability to attain and sustain a hard and firm erection. In other words, it results in erectile dysfunction or impotence.

Another crucial aspect that gets impaired with age and affects your sexual function is the blood circulation to the penis. Poor blood flow to the penis is also an underlying factor in erectile dysfunction. Not only this, your testosterone levels also plummet with age. Since it is the hormone that regulates sex drive and sexual function in men, a decline in testosterone inevitably results in reduced sex drive which triggers erectile dysfunction.

Nonetheless, there are some natural ways to get over the above problems. L-arginine helps in the secretion of nitric oxide. It is an amino acid that not only helps enhance sex drive but also helps you gain muscle. This is the reason why most bodybuilders take L-arginine supplements.

Food sources of L-arginine include animal protein, dairy, poultry, nuts and beans etc.,

Apart form L-arginine, there are some herbs that have been used for thousands of years to enhance blood circulation and overcome sexual dysfunction. Some of such herbs include ginseng, ginkgo, tribulus terrestris etc.,

There are some supplements that are packed with the above herbs and amino acids and have gained immense popularity not just because they are highly effective but also because they are completely safe and devoid of any side effects.

Check out more on Nitric Oxide and Male Libido and natural or herbal supplements for men.

Generally yeast infections are considered to be an only ‘woman’s problem’, but yeast infections are also occur in some males. Often it is truly ignored problem and as a result, it goes undiagnosed.

Likely a lot of women are suffering from a vaginal infection and as an indication that things are amiss in their body. While men have absolutely no clear conception that they may have male yeast infection until it generates further big problems with their physical condition. Even most men will get through the life never knowing that they have a Candida or fungal infection since it is very difficult to identify.

Yeast infection can occur at variety of body areas like mouth, underarms, vagina, penis etc.

Male yeast infection can happen in men of all ages.

Symptoms of Candida in Men (Males):

Penile Itching

Feel burning on or after passing urine

Rash or redness on the penis or scrotum

Much painful sexual intercourse

Penis itching after sex

More Significant Signs of Male Infection:

Tongue with white coat

Short term memory loss

Dizzy feeling

Desire for sweet substances

Frequent digestion problems

Irregularity in heart beat

How it is occurring to the men

1) Men can also get a yeast infection from their partner so if their wife or girlfriend is suffering one; the yeast infection pass on to their wife or girlfriend through sexual intercourse, where it will travel up the vaginal canal, which is a perfect environment for the growing of fungus.

2) Men be able to expand a yeast infection is through drinking huge quantities of beer. As beer usually is prepared from yeast, it will come into their system this way and may perhaps grow into skin yeast on their reproductive organ. Because the circumstance in this area of the body is suitable for keeping the infection dormant and it can go unnoticed for a substantial period of time.

3) Male yeast infections may take place due to the prolonged use of antibiotics. These bacteria can kill the microorganisms that keep the growth of the fungus Candida albicans in confirm. Thus, the fungus will grow quickly.

Very often yeast infections are taken for granted at an early stage. This is one big mistake that many men do. If fact if the yeast infection symptoms are ignored it will allow? the infection to become more chronic and more complicated to get rid of. Also if not taken care appropriately, the yeast infection can affect your health; leaving you with constant irritation, depressed and rashes. Here are a few symptoms that hopefully will get you alarmed.

- Swelling joints

If not taken care of, yeast can spread to almost all parts of the body. Take some time to clean joints dry after each shower.

- Inflamed genital area

Most often the head of the penis will be red, constantly itching and having flaky dry skin. Also you may notice some unusual discharge and pain while peeing.

- Oral thrush

You may notice yellow or whitish spots under your tongue. This will be accompanied by bad breath along with pain while swallowing.

You can try lots of home remedies to get rid of your yeast infection. If you have already searched around, yoghurt is the number one recommended cure for yeast infection. Vinegar and garlic are also suggested but some find it really painful to apply these two on the infected area. Thus yoghurt stays the favorite. Believe me when I say that most people who have tried over the counter drugs have had problems with those. Either making the yeast infection more complicated than before or not getting rid of it at all.

You must be aware that yeast is originally present in our body, there are the good and the bad ones. Yeast infection occurs when the body pH is disturbed for whatever reason. So, while getting read of the infection you should make sure to get the ride medication so that the good ones are not eradicated too.

Yeast infections are commonplace for women, but did you know that males can get it as well? However, since males rarely get them, it might just seem like a rumor that men can suffer the same problems. Men can contract candidiasis or a male yeast infection that will cause them pain and discomfort. For this reason, men need to be just as informed as a woman is in order to avoid them.

These infections in men are not categorized as a sexually transmitted disease, but it is possible for an unaffected man to get it from an infected woman. However, many doctors will recommend that men check their female partner prior to having intercourse. If the woman is infected, it is not recommended for the man to have sexual intercourse until the infection clears.

One cause of? the disease can be using condoms that have nonxynol-9, a common spermicide. Research has shown that this spermicide can develop? yeast related problems for both men and women. Oral thrush or an infection in the mouth can be caused by a number of factors, including some of the following:

?* Antibiotic medications

?* Lowered immune system during an illness

?* A diet high in sugar (which yeast feeds on)

?* Smoking

Some men have gotten an oral yeast infection from drinking heavy amounts of alcohol, which contains the sugar and yeast that the infection thrives from, creating overproduction.

Some of the signs of a male yeast infection include a red, sore or itchy penis, especially on the head. There might be tiny blisters accompanied with small red bumps that itch. Just like the female version, there might be a white and thick discharge that smells like yeast as well. If these symptoms appear and you have not experienced them before, visit your doctor to get the right diagnosis.

If you think you have an infection, start treatment right away to see a fast cure for yeast infection. Many men see an immediate relief from their symptoms using an over-the-counter topical cream that can help to reduce the infection on the penis. If you use these creams two times a day for a week or two, you will see your symptoms alleviate and disappear. In addition, an oral tablet can be used. If you are struggling with oral thrush, you can take antifungal tablets in pill form, liquids or lozenges that will reduce the problem.

Since many of the treatments offered with a yeast infection can be harsh on the skin, some men and women elect to use natural solutions like yogurt to treat the condition.

When it is all about sexual pleasure, there is no compromise; either for a woman or for a man. Unfortunately, man suffers more than woman about sexual dysfunction since there are many chances that male reproductive system and its organs to get affected due to plenty of factors. Erectile dysfunction is one of the major concerns that have hit millions of men across the world; irrespective of the race, breed and region.

There are plenty of ways to treat and heal erectile dysfunction. However, the treatment generally depends upon the cause that has given rise to this sexual problem. For example, if the issue is due to some obstruction, it can be removed by surgeries. However, as with other surgeries, surgery for erectile dysfunction may also bring some unwanted, side and adverse effects and that is why, more and more men now prefer to undergo natural remedies to treat erectile dysfunction.

Let us now learn some natural remedies for erectile dysfunction:-

Remedy 1: There are many exercises that help in overcoming this problem. A man can perform Kegel exercise that helps developing pelvic muscles and hence, may help in strengthening the penis structure. This can help in good and fuller erections.

Remedy 2: There are many herbs that help in treating the problem of erectile dysfunction. One can go for either single herb or can go for some formula that contains the blend of the herbs that work as natural aphrodisiacs. Herbs such as shatavari, Ashwagandha, mucuna, butea, Shilajit etc are considered to be very beneficial in treating this problem. They all have different actions on male reproductive systems and its organs. But generally, the herbs those are labeled as natural aphrodisiacs improve the blood circulation within the male reproductive organs so that they get better in performance. In case of erectile dysfunction, such herbs improve the blood circulation in penis and also strengthen the muscles of the penis that give it better, fuller, firmer and longer erection to perform its best before and during the sexual acts such as foreplays and mainplays.

Remedy 3: Diet also plays some role in treating this male sexual health problem. It is observed that a man who is in addiction of liquor or any other form of alcohol and one who smokes is more prone to suffer from male sexual problems like premature ejaculation and loss of libido. Hence, give up smoking and alcohol. One should also consume a lot of dark, green and leafy vegetables so that they provide enough vitamins and essential minerals that help in getting good erections.

Remedy 4: If erectile dysfunction is because of any mental disorder then it is better to adopt some brain calming therapies such as holistic exercises - yoga and Pranayama. Meditation has favorable results in treating this male sexual problem. However, to get good results, one has to perform them regularly for a period of months.